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Short asymmetric synthesis of (2S,3S)- and (2S,3R)-3-prolinoglutamic acids: 2-carboxy-3-pyrrolidine-acetic acids (CPAA)

✍ Scribed by Philippe Karoyan; Gérard Chassaing

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
63 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

The asymmetric synthesis of both cis and trans 3-prolinoglutamic acids can be easily achieved in a diastereoselective and enantioselective way via the amino-zinc-enolate cyclisation.

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