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Asymmetric total synthesis of (2S,3S)-3-hydroxypipecolic acid

โœ Scribed by Subhash P. Chavan; Nilesh B. Dumare; Kishor R. Harale; Uttam R. Kalkote

Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
313 KB
Volume
52
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A synthetic route to (2S,3S)-3-hydroxypipecolic acid was achieved from readily available nonchiral pool starting material cis-2-butene-1,4-diol and involved Claisen orthoester rearrangement, Sharpless asymmetric dihydroxylation and intramolecular lactamisation of azido lactone as the key steps.

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