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Asymmetric synthesis of (2S,4R)-4-hydroxypipecolic acid

โœ Scribed by Clinton A Brooks; Daniel L Comins


Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
84 KB
Volume
41
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


An asymmetric synthesis of (2S,4R)-4-hydroxypipecolic acid was accomplished in eight steps and 31% overall yield.


๐Ÿ“œ SIMILAR VOLUMES


Stereoselective Synthesis of (2S,4R)-4-H
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## Abstract A new synthetic route to enantiopure (2__S__,4__R__)โ€4โ€hydroxypipecolic acid from commercial ethyl (3__S__)โ€4โ€chloroโ€3โ€hydroxybutanoate is reported. The synthesis is based on the Pdโ€catalyzed methoxycarbonylation of a 4โ€alkoxyโ€substituted ฮดโ€valerolactamโ€derived vinyl triflate followed b

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