Both 2S,3R-[2,3-2H2]-serine 5 and 2S,3S-[3-2H]-serine 6 have been pre ared from (E)-methyl-[2,3-2H2]-acrylate and (Z)-ethyl-[3-qH]-acrylate, respectively. The acrylate esters were converted to a mixture of isomeric bromohydrins by treatment with N-bromoacetamide. The ratio of 2-bromo-3-hydroxy speci
Assymetric synthesis of (2S,3R)- and (2S,3S)-[2-13C;3-2H] glutamic acid
✍ Scribed by Kosuke Okuma; Akira M. Ono; Seiji Tsuchiya; Makoto Oba; Kozaburo Nishiyama; Masatsune Kainosho; Tsutomu Terauchi
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 358 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4039
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2-Ethoxy-1-methyl-5-pymlidinone (1) was reacted with ethyl [3,4-'3C2]acetoacetate (2) in the presence of T i c 4 to give ethyl [3,4-13C2]-2-( 1'-methyl-5'oxo-2'-pyrrolidinyl)-3-oxobutanoate (3) in 85% yield. Decarboethoxylation of ethyl [3,4-13C2]-2-( l'-methyl-5'-oxo-2'-pyrrolidiny1)-3-oxobutanoate
## Abstract The first synthesis of doubly labeled, [2‐^13^C, 4‐^13^C]‐(2__R__,3__S__)‐catechin 15 and [2‐^13^C, 4‐^13^C]‐(__2R__,3__R__)‐epicatechin 18 starting from labeled 2‐hydroxy‐4, 6‐bis(benzyloxy)acetophenone 3 and labeled 3, 4‐bis(benzyloxy)‐benzaldehyde 7 are described. Copyright © 2010 Jo
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Epoxy ring opening of 2 and 2 with [ l -1 4 C ] hexadecyl copper lo gave respectivezy t h e analog 4 of agaric acid trimethyl e s t e r and methy2 b -1 4 ~J a g a r i c a t e 5, which-was hydrolysed t o -& by Zithium hy-&oxide i n I, 2-dimethoxyethane (DME). Epoxy ring trans opening of -2 with d i