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Synthesis of enantiomerically pure (1S, 2R)-epoxy indane and cis-(1R,2S)-2-amino-1-indanol

✍ Scribed by Anton Mitrochkine; Franck Eydoux; Monique Martres; Gérard Gil; Andreas Heumann; Marius Réglier


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
201 KB
Volume
6
Category
Article
ISSN
0957-4166

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Synthesis of enantiomeric diethyl (1R,2R
✍ Andrzej E. Wróblewski; Katarzyna B. Balcerzak 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 540 KB

Addition of diethyl phosphite to 2,3-O-cyclohexylidene-D-glyceraldehyde catalyzed by triethylamine or fluorides led to ca. 35:65 mixtures of diethyl (IR,2R)-and (1S,2R)-2,3-O-cyclohexylidene-l,2,3trihydroxypropylphosphonates (4a) and (4b). Application of lithium diethylphosphonate only slightly impr