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Synthesis of enantiomerically pure (1R,2S)- and (1S,2R)-2-Amino-1,2-bis(pentafluorophenyl)ethanols

✍ Scribed by Takashi Sakai; Kazuhiro Kubo; Setsuo Kashino; Kenji Uneyama


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
221 KB
Volume
7
Category
Article
ISSN
0957-4166

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Synthesis of enantiomeric diethyl (1R,2R
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Addition of diethyl phosphite to 2,3-O-cyclohexylidene-D-glyceraldehyde catalyzed by triethylamine or fluorides led to ca. 35:65 mixtures of diethyl (IR,2R)-and (1S,2R)-2,3-O-cyclohexylidene-l,2,3trihydroxypropylphosphonates (4a) and (4b). Application of lithium diethylphosphonate only slightly impr