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Synthesis of ( E )-4-Hydroxydimethylallyl Diphosphate. An Intermediate in the Methyl Erythritol Phosphate Branch of the Isoprenoid Pathway

✍ Scribed by Fox, David T.; Poulter, C. Dale


Book ID
126161752
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
41 KB
Volume
67
Category
Article
ISSN
0022-3263

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Optically pure 2-C-methyl-d-erythritol 4-phosphate, a key intermediate in the mevalonate-independent route for isoprenoid biosynthesis, is conveniently synthesized from 1,2-O-isopropylidene-a-d-xylofuranose, including the possibility of radiolabeling of this substrate.