Synthesis of DL-5,5′-dihydroxyleucine the reduction product of γ carboxy glutamic acid
✍ Scribed by S. Bory; M. Gaudry; A. Marquet; R. Azerad
- Book ID
- 118313805
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 393 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0006-291X
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A protocol is given for the synthesis, by a simple enzyme preparation, of the L-isomers of glutamic acid y-semialdehyde and N-acetylglutamic acid y-semialdehyde. The isolation and physical and chemical properties of these products as the 2,4-dinitrophenylhydrazone derivatives are described. Spectral
By condensing diethyl ethoxymethylenemalonate with diethyl acetamidomalonate, 5-hydroxy-2,4-dicarbethoxypyrrole was prepared. Hydrogenation over Pt-C to 5-oxo-2,4-dicarbethoxypyrrolidine, followed by alkaline hydrolysis gave y-carboxyglutamate. Mild alkaline hydrolysis yielded 5-oxo-2,4-pyrrolidine