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Synthesis of dimethyl 5, 5, 6, 6 (2H4)-2-oxoheptylphosphonate, a deuterium labelled prostaglandin intermediate

✍ Scribed by Claus O. Meese; Bernd Borstel

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
388 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of the specifically labelled versatile prostaglandin intermediate 1b is described which involves the preparation of 2,2,3,3 (^2^H~4~)butyliodide 6b via homogenous catalytic deuteration of the acetylene 4. Examples for the preparation of prostaglandins and extensive spectroscopic data are included.

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