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Synthesis of deuterium and tritium labeled 2-acetamido- 5,6-dimethylbenzimidazole

✍ Scribed by Richard S. P. Hsi; Louis L. Skaletzky

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
315 KB
Volume
17
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Synthesis of 2‐acetamido‐5,6‐dimethylbenzimidazole, labeled with deuterium and tritium at the 4‐ and 7‐Dositions of the benzimidazole ring system, is described. 4,5‐Dimethyl‐O‐phenyl‐enediamine is deuterated and tritiated in the 3‐ and 6‐positions by means of exchange with deuterated and tritiated water. These relatively labile labels are rendered stable after formation of the benzimidazole rinq system. The stability of the labels in 2‐acetamido‐5,6‐dimethyl[4,7‐^3^H]benzimidazole is ascertained.

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