## Abstract The synthesis of the specifically labelled versatile prostaglandin intermediate __1b__ is described which involves the preparation of 2,2,3,3 (^2^H~4~)butyliodide __6b__ via homogenous catalytic deuteration of the acetylene __4__. Examples for the preparation of prostaglandins and exten
Dimethyl 3,4,5,6-[2H4] -2-oxoheptylphosphonate: A readily available reagent for the preparation of deuterated prostanoids-application to the synthesis of 2H4-labelled (±)-prostaglandin D2
✍ Scribed by Claus O. Meese; Sabine Holzer
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 606 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0022-2135
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An efficient preparation of the title compound la starting from propargyl alcohol and proceeding via deuterated monomethyl adipate (&) is described. As demonstrated by t h e first total synthesis of deuterated w-carboxy-thromboxane B2 (&I, may serve as a versatile starting compound for t h e synthes
3 H]-Labelled 4- [ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]-2,3-[ 3 H]-butan-1-ol (3b) was prepared as a novel non-peptidic radiolabelled high affinity antagonist of the corticotropin-releasing hormone type 1 receptor (CRHR 1 ) that could be useful as a more