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Dimethyl 3,3,4,4,.5,.5,6,6-(2H8)-6-methoxycarbonyl-2-oxo-hexanephosphonate, a versatile reagent for the synthesis of deuterated ω-carboxy prostanoids

✍ Scribed by Claus O. Meese; Otto Fürst; Bernd Borstel

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
577 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

An efficient preparation of the title compound la starting from propargyl alcohol and proceeding via deuterated monomethyl adipate (&) is described. As demonstrated by t h e first total synthesis of deuterated w-carboxy-thromboxane B2 (&I, may serve as a versatile starting compound for t h e synthesis of various w -carboxy prostanoic acid metabolites.

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