✦ LIBER ✦

Synthesis of deuterium labelled ibuprofen

✍ Scribed by Vincent J. Capponi; Gordon W. Halstead; Donald L. Theis

Publisher: John Wiley and Sons
Year: 1986
Tongue: French
Weight: 400 KB
Volume: 23
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580230209

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✦ Synopsis

The preparations o f [ar-2H4]-ibuprofen and Car, 3,3,3-2H7]-i buprofen are described. The deuterium was incorporated i n t o t h e aromatic ri,Fg o f [ar-2H+ ibuprofen which i s a m e t a b o l i c a l l y s t a b l e p o s i t i o n . [ar,3,3,3-H ]-ibuprofen was synthesized by t h e same r o u t e u s i n g c2H3]-CH I i n s t e a d o f CH f f o r use as a K / M S i n t e r n a l standard i n s t a b l e i s o t o p e l a b e l l e d b i o a v a i l a b i l i t y studies.

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