The preparations o f [ar-2H4]-ibuprofen and Car, 3,3,3-2H7]-i buprofen are described. The deuterium was incorporated i n t o t h e aromatic ri,Fg o f [ar-2H+ ibuprofen which i s a m e t a b o l i c a l l y s t a b l e p o s i t i o n . [ar,3,3,3-H ]-ibuprofen was synthesized by t h e same r o u t e
Preparation of enantiomerically-active deuterium-labelled ibuprofen
✍ Scribed by Ching-Shih Chen; Debra Copeland; Shawn Harriman; Yeuk-Cheun Liu
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- French
- Weight
- 348 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The chemoenzymatic preparation of optically‐active [3,3,3‐^2^H~3~]‐ibuprofen and [2‐^2^H]‐ibuprofen are described.
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