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Preparation of deuterium labelled catecholamines

✍ Scribed by Lakshmi D. Saraswat; Janis M. Kenny; Sharon K. Davis; Joseph B. Justice

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
308 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The preparation of deuterium labelled catecholamines and their metabolites is described. The procedures involve simple treatment of the compounds in DC1/D~2~O solution. Mass spectra of these labelled compounds — as their PFP or TFA derivative — are presented. The relative intensity of ions suitable for selective ion monitoring are given for each compound. Results are presented concerning ease or difficulty of deuteration. The compounds studied include dopamine, tyramine, 3‐methoxytyramine, norepinephrine, metanephrine, normetanephrine, homovanillic acid and dihydroxyphenylacetic acid.

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