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Synthesis of deuterium labelled 2-bromobenzylamine by directed ortho-metalation chemistry

✍ Scribed by Jens Atzrodt; Volker Derdau

Publisher: John Wiley and Sons
Year: 2005
Tongue: French
Weight: 100 KB
Volume: 48
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.912

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✦ Synopsis

Directed ortho-metalation (DoM) strategy has been applied for the development of a short procedure for the regiospecific synthesis of [phenyl-2 H 4 ]-2-bromo-benzylamine 6 starting from commercially available [phenyl-2 H 5 ]-benzoyl chloride 1. A strong isotope effect was observed during the ortho-substitution.

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