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Synthesis of deuterium-labeled zaleplon-d5 as an internal standard

✍ Scribed by Ajam C. Shaikh; Chinpiao Chen

Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
179 KB
Volume
51
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Zaleplon is licensed for the short‐term treatment of insomnia. Excessive usage causes side effects; hence, the drug is controlled. Identifying zaleplon in a drug abuser requires an isotope‐labeled internal standard. This work presents a synthesis of stable isotope‐labeled internal standard for zaleplon, zaleplon‐d~5~, by a five‐step synthetic sequence. Copyright © 2008 John Wiley & Sons, Ltd.

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