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Synthesis of deuterium-labeled felbamate from diethyl phenylmalonate

✍ Scribed by Yong M. Choi; Norbert Kucharczyk; R. Duane Sofia

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
202 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

USA

A synthesis of felbamate-d, (2-phenyl-1,3-propanediol-l,l,3,3-d, dicarbamate) starting from diethyl phenylmalonic acid ester and lithium aluminum deuteride was developed. material to felbamate-d, via the intermediate, 2-phenyl-1,3-propanediol- 1,1,3,3-d,.

The final overall yield was 44%. The isotope purity was 99.2%.

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