This paper describes the synthesis of deuterium‐labeled pregabalin. The stable isotopic‐labeled compound was obtained in nine steps starting from the commercially available 4‐[^2^H~11~]methylvaleric acid as the stable‐labeled reagent. It is used as an internal standard for analysis and metabolic stu
Synthesis of deuterium labeled phenethylamine derivatives
✍ Scribed by Ya-Zhu Xu; Chinpiao Chen
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- French
- Weight
- 161 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Several methods for the specific deuteration of cannabmoids are described. Deuteration of the phenolic ring was accomplished by treatment with BF, .Et10 followed by quenching with a solution of Na, CO, in Da 0 resulting in deuterium incorporation in both the 2 and 4 positions. Regioselective incorpo
## Abstract Ethyl isocyanate, N‐methylacetamide, N‐methylacetamide‐d3, and __N__‐methylacetamide‐d6 were reduced with lithium aluminum deuteride and then nitrosated with sodium nitrite to yield, respectively, nitrosomethyl (‐__d__3) ethylamine, nitrosomethylethyl (α‐**d2**) amine, nitrosomethylethy