Ribonucleosides, chlorobis(amino)phosphines and thiols react via phosphorothioamidites to form phosphorothioites. Oxidation with sulphur gives ribonucleoside phosphorodithioate trtesters which after deprotection yiekls the phosphorodithioate ribonucleoside analogues. Recently, chemical synthesis of
β¦ LIBER β¦
Synthesis of deoxycytidine oligomers containing phosphorodithioate linkages
β Scribed by Ana Grandas; William S Marshall; John Nielsen; Marvin H Caruthers
- Book ID
- 104227058
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 513 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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## Abstract A properly protected 5βmethylated deoxycytidine (5mC) derivative has been synthesized and applied to assemble DNA fragments containing 5mCG, 5mCC and 5mC5mC sequences.