Chemical synthesis of dimer ribonucleotides containing internucleotidic phosphorodithioate linkages

✍ Scribed by Kenneth H. Petersen; John Nielsen

• Book ID: 104226686
• Publisher: Elsevier Science
• Year: 1990
• Tongue: French
• Weight: 300 KB
• Volume: 31
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)94661-6

✦ Synopsis

Ribonucleosides, chlorobis(amino)phosphines and thiols react via phosphorothioamidites to form phosphorothioites. Oxidation with sulphur gives ribonucleoside phosphorodithioate trtesters which after deprotection yiekls the phosphorodithioate ribonucleoside analogues.

Recently, chemical synthesis of oligodeoxyribonucleotides containing internucleotidic