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Synthesis of covalently immobilized phospholipid analogues

✍ Scribed by M. Wurl; D. Enterling; H. Kunze

Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 357 KB
Volume: 37
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(85)90085-4

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✦ Synopsis

Cyclic l-O-acyl-2-O-alkyl-glyccro-3-phosphotriesters and I-O-acyl-2-O-alkyl-glyccro-3bromocthylphosphate with a free acyl moiety in position 1 of the glycerol backbone were synthesized. These phospholipid intermediates were covalently bound to AH-Sepharosc via the carbodiimide method. After immobilization the corresponding phosphatidylethanolaminc analogues were obtained by acid hydrolysis of the cyclic phosphotriesters and by direct amination of the bromoethylphosphate. Thus, in a short, stepwise synthesis including minimum use of protecting groups, a variety of immobilized phospholipid analogues are available as attinity adsorbents for the purification of enzymes related lo phospholipid metabolism.

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