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Phase behaviour of novel phospholipid analogues

✍ Scribed by George S. Attard; Christopher McGuigan; Andrew Mackenzie

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 562 KB
Volume: 76
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(94)02423-3

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✦ Synopsis

The phase behaviour of phospholipid analogues containing a phosphoramide moiety was investigated using polarized light microscopy. A complex liquid-crystalline polymorphism consisting of lamellar, and normal topology hexagonal and intermediate phases was observed and found to depend on the structure of the phosphoramide headgroup and its methylation. In addition, a lower consolute phase boundary in the micellar solution part of the phase diagram was observed in some systems. The aggregation behaviour of these novel amphiphiles was compared with that of quaternary ammonium and oligo-ethylene oxide amphiphiles.

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