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Syntheses of arsinolipids: non-isosteric analogues of phospholipids

โœ Scribed by Nick L. Kordalis; Panayiotis V. Ioannou

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
77 KB
Volume
14
Category
Article
ISSN
0268-2605

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โœฆ Synopsis

Reaction of alkaline benzenearsonous and 2,3dihydroxypropylarsonous acids with rac-glycidol affords the corresponding arsinic acids, which after reduction with thiophenol are acylated with either fatty-acid chlorides/pyridine or fatty acids/dicyclohexylcarbodiimide/4dimethylaminopyridine and oxidized with hydrogen peroxide to give the arsinolipids (rac-2,3diacyloxypropyl)phenylarsinic and bis-(rac-2,3diacyloxypropyl)arsinic acids. The latter is a non-isosteric analogue of bisphosphatidic acid.

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