Synthesis of Isosteric Analogues of Acylglycosylglycerols Active as Chemoprevention Agents

✍ Scribed by Federica Compostella; Diego Colombo; Patrizia Ferraboschi; Antonio Scala; Lucio Toma; Fiamma Ronchetti

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 320 KB
• Volume: 2002
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/1099-0690(200204)2002:8<1429::aid-ejoc1429>3.0.co;2-2

✦ Synopsis

Monoacylated glycosylglycerols are known anti-tumor promoters: in order to study the role of the ester function in the modulation of their activity, we synthesized several analogues in which the acyloxy moiety was substituted with isosteric chains linked to the glycosylglycerol skeleton through an ether or a ketone functionality or simply by a C-C bond. Depending on the position of the chain, the key steps in the