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Synthesis of Coenzyme Q10

✍ Scribed by Eun-Taek Oh; Hee Jin Kim; Jung Taek Oh; Liang Su; Inkyun Yun; Kyunggu Nam; Jae-Hong Min; Joon Woo Kim; Sangho Koo


Book ID
112082964
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
533 KB
Volume
2012
Category
Article
ISSN
1434-193X

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Deuterium-labelled coenzyme Q 10 ([2-CD 3 -1 0 -CD 2 ]coenzyme Q 10 , coenzyme Q 10 -d 5 ) was synthesized by condensation of 2,3-dimethoxy-[5-CD 3 ]methyl-1, 4-hydroquinone with [1-CD 2 ]decaprenol. Five positions were selected for deuteration as replacement at these positions allowed examination o

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## Abstract Radio‐labelled coenzyme Q~10~, labelled at the 3′‐position with ^14^C, was synthesized starting from natural solanesol and ethyl [3‐^14^C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3‐^14^C] acetoacetate. The specific radioactivity of the product was 44.8 ΞΌCi, 1.66 MBq/m

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