✦ LIBER ✦

Synthesis of carbon-14 labeled pyraoxystrobin, a novel fungicide

✍ Scribed by Xun-yue Liu; Qing-fu Ye; Deng-lei Kan; Zheng Zhang; Xing-cheng Ding

Publisher: John Wiley and Sons
Year: 2011
Tongue: French
Weight: 239 KB
Volume: 54
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1929

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✦ Synopsis

SYP‐3343, (E)‐2‐(2‐((3‐(4‐chlorophenyl)‐1‐methyl‐1H‐pyrazole‐5‐yloxy)methyl)) phenyl)‐3‐methoxyacrylate, is a novel fungicide with broad‐spectrum and high activity against fungi. In this paper, radioactive pyraoxystrobin, labeled in the pyrazole ring system was achieved from ^14^C labeled 4‐chlorobenzoic acid through substitution, cyclization, and condensation, in an overall chemical and radiochemical yield of 44%. The chemical and radiochemical purity of the title compound was 98.5% and 98.2%, respectively. This labeled SYP‐3343 was used as a radiotracer for metabolism, toxicology, mode of action, and other environmental studies. Copyright © 2011 John Wiley & Sons, Ltd.

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