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Synthesis of carbon-11 labeled diprenorphine: A radioligand for positron emission tomographic studies of opiate receptors

✍ Scribed by John R. Lever; Robert F. Dannals; Alan A. Wilson; Hayden T. Ravert; Henry N. Wagner Jr.

Book ID
108383147
Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
224 KB
Volume
28
Category
Article
ISSN
0040-4039

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✍ John R. Lever; Chris M. Kinter; Hayden T. Ravert; John L. Musachio; William B. M πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 French βš– 508 KB

## Abstract A delta opioid receptor antagonist, N1′‐methylnaltrindole (MeNTI), has been labeled with carbon‐11. The precursor for radiolabeling was prepared in 71% yield by benzylation of the phenolic moiety of naltrindole. Alkylation of the indole nitrogen using [^11^C]iodomethane and aqueous tetr