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Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)

โœ Scribed by Kun-Eek Kil; Yu-Shin Ding; Kuo-Shyan Lin; David Alexoff; Sung Won Kim; Colleen Shea; Youwen Xu; Lisa Muench; Joanna S. Fowler


Book ID
116799063
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
723 KB
Volume
34
Category
Article
ISSN
0969-8051

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Rapid synthesis of 11C-labeled FK506 for
โœ Yoshihiro Murakami; Akio Kuroda; Kazuhiko Osoda; Shintaro Nishimura ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 205 KB

The present study describes a rapid synthesis method for labeled [ 11 C]FK506 for positron emission tomography (PET). A one-pot reaction from [ 11 C]CH 3 I, involving a Wittig reaction as the key carbon carbon bond formation was developed. The chemical process was accomplished using a designed, full