Rapid synthesis of 11C-labeled FK506 for positron emission tomography

✍ Scribed by Yoshihiro Murakami; Akio Kuroda; Kazuhiko Osoda; Shintaro Nishimura

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 205 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02705-3

✦ Synopsis

The present study describes a rapid synthesis method for labeled [ 11 C]FK506 for positron emission tomography (PET). A one-pot reaction from [ 11 C]CH 3 I, involving a Wittig reaction as the key carbon carbon bond formation was developed. The chemical process was accomplished using a designed, fully automated synthetic apparatus, and an injectable solution of [ 11 C]FK506 was obtained in only 34 min from [ 11 C]CH 3 I. The decay-corrected radiochemical yield based on [ 11 C]CH 3 I was 11.9%, and the specific activity was 39.8 GBq/mmol.