✦ LIBER ✦

Synthesis and carbon-11 labeling of (R)- and (S)-thionisoxetine, norepinephrine reuptake inhibitors, potential radioligands for positron emission tomography

✍ Scribed by Maria Azzurra Filannino; Mario Matarrese; Elia Anna Turolla; Valeria Masiello; Rosa Maria Moresco; Sergio Todde; Elisa Verza; Fulvio Magni; Angela Cattaneo; Angela Bachi; Marzia Galli Kienle; Ferruccio Fazio

Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 234 KB
Volume: 65
Category: Article
ISSN: 0969-8043
DOI: 10.1016/j.apradiso.2007.06.004

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis and PET evaluation of (R)-[S-m

Synthesis and PET evaluation of (R)-[S-methyl-11C]thionisoxetine, a candidate radioligand for imaging brain norepinephrine transporters

✍ Magnus Schou; Victor W. Pike; Andrea Varrone; Balázs Gulyás; Lars Farde; Christe 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 164 KB

## Abstract __Introduction:__ (__R__)‐3‐(2‐(methylthio)phenoxy)‐__N__‐methyl‐3‐phenylpropan‐1‐amine [(__R__)–thionisoxetine; **1**] is a potent inhibitor of the norepinephrine transporter (NET). We aimed to label **1** with carbon‐11 (__t__~1/2~ = 20.4 min) for evaluation as a radioligand for imagi

Synthesis, enantiomeric resolution, and

Synthesis, enantiomeric resolution, and selective C-11 methylation of a highly selective radioligand for imaging the norepinephrine transporter with positron emission tomography

✍ Kuo-Shyan Lin; Yu-Shin Ding 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB 👁 1 views

An improved synthesis of carbon-11 label

An improved synthesis of carbon-11 labeled acetoacetic acid and an evaluation of its potential for the investigation of cerebral pathology by positron emission tomography

✍ G.H.M. Prenen; K.G. Go; F. Zuiderveen; A.M.J. Paans; W. Vaalburg 📂 Article 📅 1990 🏛 Elsevier Science ⚖ 625 KB

1-11C-acetoacetic acid was synthesized by carboxylation of the acetone carbanion. Purification was carried out using HPLC. The product was obtained with a radiochemical yield of up to 58%, corrected for decay, in a total preparation time of 30 min. The distribution of 1-11C-acetoacetic acid after in

Synthesis and biological evaluation of S

Synthesis and biological evaluation of S-[11C]methylated mercaptoimidazole piperazinyl derivatives as potential radioligands for imaging 5-HT1A receptors by positron emission tomography (PET)

✍ Raquel Garcia; Catarina Xavier; António Paulo; Isabel Santos; Torsten Kniess; R. 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 157 KB

The novel 2-mercaptoimidazole derivatives, 1-[4-((2-methoxyphenyl)-1-piperazinyl)butyl]-2-mercaptoimidazole (3) and methyl[4-((2-methoxyphenyl)-1-piperazinyl))butyl] (2-mercapto-1-methylimidazol-5-yl)methanamide ( 8), were efficiently labelled with 11 C through methylation of the thioketone function

Fully automated high yield synthesis of

Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring P-glycoprotein function with positron emission tomography

✍ Gert Luurtsema; Albert D. Windhorst; Martien P.J. Mooijer; Jacobus D.M. Herschei 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 118 KB 👁 1 views

## Abstract Racemic (±) verapamil is a well characterized substrate for P‐glycoprotein (P‐gp). However, the __in vivo__ pharmacokinetics and pharmacodynamics of both enantiomers are reported to be different. In the preparation of evaluation studies of both enantiomers in animals and humans, the pur