✦ LIBER ✦
An improved synthesis of carbon-11 labeled acetoacetic acid and an evaluation of its potential for the investigation of cerebral pathology by positron emission tomography
✍ Scribed by G.H.M. Prenen; K.G. Go; F. Zuiderveen; A.M.J. Paans; W. Vaalburg
- Publisher
- Elsevier Science
- Year
- 1990
- Weight
- 625 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0883-2889
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✦ Synopsis
1-11C-acetoacetic acid was synthesized by carboxylation of the acetone carbanion. Purification was carried out using HPLC. The product was obtained with a radiochemical yield of up to 58%, corrected for decay, in a total preparation time of 30 min. The distribution of 1-11C-acetoacetic acid after injection into adult Wistar rats and cats was investigated by PET. When the tracer was injected into cats, 3 weeks after inflicting a unilateral freezing lesion upon the brain, accumulation of 1-11C-acetoacetic acid in the ipsilateral brain hemisphere was observed.