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Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

โœ Scribed by Ahmed Kamal; O Srinivas; P Ramulu; G Ramesh; P.Praveen Kumar


Book ID
108073344
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
276 KB
Volume
14
Category
Article
ISSN
0960-894X

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โœ Ahmed Kamal; G. Ramesh; P. Ramulu; O. Srinivas; Tasneem Rehana; G. Sheelu ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 183 KB

Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that posses cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies.