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Synthesis of C-8 Alkylamino Substituted Pyrrolo[2,1-c][1,4]benzodiazepines as Potential Anticancer Agents.

โœ Scribed by Ahmed Kamal; N. Laxman; G. Ramesh; O. Srinivas; P. Ramulu


Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
33
Category
Article
ISSN
0931-7597

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Synthesis of Sequence-Selective C8-Linked Pyrrolo(2,1-c)(1,4) benzodiazepine DNA Interstrand Cross-Linking Agents. -In order to construct the key A-ring fragments (VI), a versatile convergent approach is developed to join two units of vanillic acid (I) with ฮฑ,ฯ‰-dihaloalkanes (II). The "amino-thioac