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Synthesis of the First Examples of A-C8/C-C2 Amide-Linked Pyrrolo[2,1-c][1,4]benzodiazepine Dimers.

โœ Scribed by Stephen J. Gregson; Philip W. Howard; David E. Thurston


Publisher
John Wiley and Sons
Year
2003
Weight
169 KB
Volume
34
Category
Article
ISSN
0931-7597

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Synthesis of Sequence-Selective C8-Linked Pyrrolo(2,1-c)(1,4) benzodiazepine DNA Interstrand Cross-Linking Agents. -In order to construct the key A-ring fragments (VI), a versatile convergent approach is developed to join two units of vanillic acid (I) with ฮฑ,ฯ‰-dihaloalkanes (II). The "amino-thioac