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Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents

✍ Scribed by Ahmed Kamal; G. Ramesh; P. Ramulu; O. Srinivas; Tasneem Rehana; G. Sheelu

Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 183 KB
Volume: 13
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(03)00743-1

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✦ Synopsis

Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that posses cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies.

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