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Synthesis of C2-symmetrical bis-β-amino alcohols and their application in the enantioselective addition of diethylzinc to aldehydes

✍ Scribed by Qianyong Xu; Hui Wang; Xinfu Pan; Albert S.C Chan; Teng-kuei Yang

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 68 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01236-9

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✦ Synopsis

The C 2 -symmetrical bis-b-amino alcohols 1-6 were prepared and especially attention is focused on bridges, which link the two b-amino alcohol units. These ligands have been applied as chiral catalysts in the asymmetric addition of diethylzinc to aldehydes. sec-Alcohols have been obtained in good yields with up to 95.4% enantiomeric excess.

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