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Synthesis of new N-sulfonylated amino alcohols and application to the enantioselective addition of diethylzinc to aldehydes

✍ Scribed by Xin-Ping Hui; Chien-An Chen; Han-Mou Gau


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
176 KB
Volume
17
Category
Article
ISSN
0899-0042

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Enantioselective addition of diethylzinc
✍ Sheng-Hsiang Hsieh; Han-Mou Gau πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 148 KB πŸ‘ 2 views

## Abstract An __N__‐sulfonylated β‐amino alcohol (__R__,__S__,__S__,__R__)‐**9** with four stereogenic centers is prepared. The titanium complex of **9** is an effective catalyst to induce excellent enantioselectivities for diethylzinc addition to aromatic aldehydes with ee values up to 99%. The f