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Synthesis of New Chiral β-Amino Alcohols Derived from Isomannide and Their Application to the Catalytic Enantioselective Addition of Diethylzinc to Aldehydes.

✍ Scribed by Byung Tae Cho; Sang Kyu Kang


Publisher
John Wiley and Sons
Year
2005
Weight
27 KB
Volume
36
Category
Article
ISSN
0931-7597

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Enantioselective addition of diethylzinc
✍ Dilek Isik Tasgin; Canan Unaleroglu 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB 👁 1 views

## Abstract β‐Amino alcohols derived from (1__R__,2__S__)‐norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. __N__‐alkylated (1__R__,2__S__)‐norephedrine‐based derivative 3a gave the highest enantioselectivity. The effects of d