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Synthesis of both enantiomers of 4-vinyl oxazolidin-2-one from a single precursor: D-isoascorbic acid

✍ Scribed by Giuliano Delle Monache; Domenico Misiti; Patrizia Salvatore; Giovanni Zappia

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
122 KB
Volume
12
Category
Article
ISSN
0899-0042

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✦ Synopsis

A convenient synthesis of (S)-and (R)-4-vinyl oxazolidin-2-one 1 and 2 from the same inexpensive starting material, D-isoascorbic acid, is described. The title compounds were obtained in 44% and 38% yield, respectively, by operationally simple steps. This approach is a suitable alternative to the literature methods and enhances the synthetic utility of these intermediates.

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