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A new synthesis of both the enantiomers of 4-amino-3-hydroxybutanoic acid (gabob) and mm2 calculations for rotamers of the intermediate oxazolidin-2-on

✍ Scribed by Alessandro Bongini; Giuliana Cardillo; Mario Orena; Gianni Porzi; Sergio Sandri

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 402 KB
Volume: 43
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)90313-8

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✦ Synopsis

The easy chromatographic separation of the diastereomeric mixture of oxaxolidin-2-onesls and s allows to synthesize pure R-(-j-& and (S)-(+)-GABOB lb. The H NMR pattern of 2 and 5 can be correlated with the configuration at C-5 and this relationship is confirmed by MM2 calculations for rotamers of 5-substituted oxazolidin-2-ones.

We have previously reported 1

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