Starting from ornithine, an efficient scalable one-pot 3-step procedure for the synthesis of the enantiopure bromo acid (I) is reported. It can be easily converted to chiral benzoylsulfanyl derivative (III), an intermediate in the synthesis of MMP inhibitors. -(HOLT, K.
A short, scaleable synthesis of both enantiomers of 2-benzoylsulfanyl-5-phthalimidopentanoic acid from ornithine
โ Scribed by Karen E. Holt; Gordon E. Hutton; C.Neil Morfitt; Graham Ruecroft; Stephen J.C. Taylor; Peter D. Tiffin; Neil Tremayne; Martin Woods
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 189 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A convenient synthesis of (S)-and (R)-4-vinyl oxazolidin-2-one 1 and 2 from the same inexpensive starting material, D-isoascorbic acid, is described. The title compounds were obtained in 44% and 38% yield, respectively, by operationally simple steps. This approach is a suitable alternative to the li
By changing the cyclisation conditions (Nail in THF or NaOEt in EtOH), an enantiopure malonamide containing an enoate acceptor afforded either diastereomeric pyrrolidin-2-one 3 or 4 as the major product of the intramolecular conjugate addition. After separation, both diastereomers were converted thr