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Synthesis of biotinylated glycosulfopeptides by chemoselective ligation

✍ Scribed by Patricia Durieux; Jimena Fernandez-Carneado; Gabriele Tuchscherer

Book ID
104230241
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
100 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Tyrosine sulfation and O-glycosylation are two post-translational modifications playing an essential role in modulation of biological activity, protein folding and cellular communication. Here, a novel chemical approach for the synthesis of biotinylated glycosulfopeptides is described based on a combination of acid labile protecting groups, highly acid sensitive resins and two orthogonal chemoselective ligation reactions.

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Synthesis of antiparallel 4Ξ±-helix bundl
Synthesis of antiparallel 4Ξ±-helix bundle TASP by chemoselective ligation
✍ OrigΓ¨ne Nyanguile; Manfred Mutter; Gabriele Tuchscherer πŸ“‚ Article πŸ“… 1994 πŸ› Springer Netherlands 🌐 English βš– 500 KB

The use of chemoselective ligation methods and orthogonal protection techniques allows access to Template-Assembled Synthetic Protein (TASP) molecules exhibiting a large variety of packing topologies. This is demonstrated for the synthesis of an antiparallel 4a-helical bundle TASP by condensing amph