✦ LIBER ✦

Synthesis of antiparallel 4α-helix bundle TASP by chemoselective ligation

✍ Scribed by Origène Nyanguile; Manfred Mutter; Gabriele Tuchscherer

Book ID: 104634708
Publisher: Springer Netherlands
Year: 1994
Tongue: English
Weight: 500 KB
Volume: 1
Category: Article
ISSN: 1573-3149
DOI: 10.1007/bf00132757

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✦ Synopsis

The use of chemoselective ligation methods and orthogonal protection techniques allows access to Template-Assembled Synthetic Protein (TASP) molecules exhibiting a large variety of packing topologies. This is demonstrated for the synthesis of an antiparallel 4a-helical bundle TASP by condensing amphiphilic peptide blocks, containing aldehyde functions at the C-or N-terminus, to a selectively addressable topological template via oxime bond formation. The resulting antiparallel 4a-helix TASP is obtained in high yield and shows a template-induced helical conformation.

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