A series of HIV-1 protease inhibitors containing an epsilon substituted lysinol backbone was synthesized. Two novel synthetic routes using N-boc-L-glutamic acid alpha-benzyl ester and 2,6-diaminopimelic acid were developed. Incorporation of this epsilon substituent enabled access to the S2 pocket of
β¦ LIBER β¦
Synthesis of (+)-biotin derivatives as HIV-1 protease inhibitors
β Scribed by Qi Han; Jennifer Lafontaine; Lee T. Bacheler; Marlene M. Rayner; Ronald M. Klabe; Susan Erickson-Viitanen; Patrick Y.S. Lam
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 212 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
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