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Two Sulfonamides-containing Dihydropyrone Derivatives as HIV Protease Inhibitors

โœ Scribed by Jae Yeol Lee; Sun Nam Kim; Chong-Kyo Lee; Hokoon Park; Yong Sup Lee


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
37 KB
Volume
334
Category
Article
ISSN
0365-6233

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The human immunodeficiency virus (HIV) codes for an aspartic protease known to be essential for retroviral maturation and replication. HIV protease is formed from two identical 99 amino acid peptides. We synthesized [(NHCH 2 CH 2 -S-CH 2 CO) [51][52] , Ala 67,95 ]HIV-1 protease using the thioether c