Epsilon substituted lysinol derivatives
โ
Kristen L.G. Jones; M. Katharine Holloway; Hua-Poo Su; Steven S. Carroll; Christ
๐
Article
๐
2010
๐
Elsevier Science
๐
English
โ 714 KB
A series of HIV-1 protease inhibitors containing an epsilon substituted lysinol backbone was synthesized. Two novel synthetic routes using N-boc-L-glutamic acid alpha-benzyl ester and 2,6-diaminopimelic acid were developed. Incorporation of this epsilon substituent enabled access to the S2 pocket of