Synthesis of biaryls via nickel-catalyzed cross-coupling reaction of arylboronic acids and aryl mesylates

✍ Scribed by Masato Ueda; Atsushi Saitoh; Saori Oh-tani; Norio Miyaura

• Book ID: 104208876
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 407 KB
• Volume: 54
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(98)00809-6

✦ Synopsis

The cross-coupling reaction of arylboronic acids (1.3 equivs) with aryl methanesulfonates was carded out in the presence of anickel(O) catalyst(3 tool%) and K3PO~,nH20 (3 equivs). The use of toluene as the solvent and the nickel(O)-dppf catalyst prepared from NiC~(dppf) plus dppf with BuLi were recognized to be the most efficient to achieve both high yields and high selectivity. The reaction can be app~ed to various electron-deficient and -rich aryl methanesulfonates to give high yields.