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ChemInform Abstract: Synthesis of Biaryls via a Nickel(0)-Catalyzed Cross-Coupling Reaction of Chloroarenes with Arylboronic Acids.

✍ Scribed by S. SAITO; S. OH-TANI; N. MIYAURA

Publisher
John Wiley and Sons
Year
2010
Weight
41 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis of Biaryls via a Nickel(0)-Catalyzed Cross-Coupling Reaction of Chloroarenes with Arylboronic Acids. -Optimized conditions are found for coupling of a wide range of chloroarenes with various functionalized arylboronic acids using K 3 PO 4 as base and dioxane or benzene as solvent. Nickel(0) catalysts in situ prepared from NiCl 2 (dppf) or NiCl 2 (PPh 3 ) in the presence or absence of additional ligands like dppf, PPh 3 , and SbPh 3 , and BuLi are recognized to be most effective. The Hammett's plot of the substituent effect of chloroarenes reveals that the reaction involves a rate-determining oxidative addition of chloroarenes to the nickel(0) complex -(SAITO, S.; OH-TANI,

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Suzuki-Type Couplin
ChemInform Abstract: Suzuki-Type Coupling of Chloroarenes with Arylboronic Acids Catalyzed by Nickel Complexes.
✍ A. F. INDOLESE πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 30 KB πŸ‘ 1 views

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