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Synthesis of azacyclic 2-deoxy-KDO

✍ Scribed by Daniel W. Norbeck; James B. Kramer

Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
190 KB
Volume
28
Category
Article
ISSN
0040-4039

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✦ Synopsis

Azacyclic analogues of 2-deoxy-KDO have been synthesized from KDO via reductive amination at C-2 and ring closure on C-6 with double inversion. CMP-KDO synthetasel catalyzes a key step in the biosynthesis of bacterial lipopolysaccharide.2 We and others3 anticipate that a novel class of antibiotics will emerge from inhibitors of this enzyme.

Kohlbrenner and Fesik4 recently demonstrated that the glycosidic linkage in CMP-KOO is 8.

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